All about fruitarianism with a long-term fruitarian, Lena

Modern diets are largely heat-processed and as a result contain high levels of advanced glycation end products (AGEs), also known as glycotoxins. Dietary advanced glycation end products (dAGEs) are known to contribute to increased oxidant stress and inflammation, which are linked to the recent epidemics of diabetes and cardiovascular disease.

Dry heat promotes new dAGE formation by 10-100 times above the uncooked state across food categories. Animal-derived foods that are high in fat and protein are generally rich in glycotoxins and prone to formation of new glycotoxins during cooking. Carbohydrate-rich foods such as vegetables, fruits, whole grains (but also milk) contain relatively few glycotoxins, even after cooking.

The formation of new glycotoxins during cooking was: 

  • prevented by the AGE inhibitory compound aminoguanidine
  • and significantly reduced by
    • cooking with moist heat,
    • using shorter cooking times,
    • cooking at lower temperatures,
    • and by use of acidic ingredients (such as lemon juice or vinegar).

Advanced glycation end products (AGEs), are a diverse group of highly oxidant compounds with pathogenic significance in diabetes and in several other chronic diseases. Glycotoxins are created through a Maillard or browning reaction - it is a part of normal metabolism, but if excessively high levels of glycotoxins are reached in tissues and the circulation they can become pathogenic, which is related to their ability to promote oxidative stress and inflammation by binding with cell surface receptors or cross-linking with body proteins, altering their structure and function.

Glycotoxins also exist in foods: they are naturally present in uncooked animal-derived foods, and cooking results in the formation of new AGEs: grilling, broiling, roasting, searing, and frying propagate and accelerate new AGE formation. Recent studies clearly show that dAGEs are absorbed and contribute significantly to the body’s AGE pool.

Avoidance of dAGEs, glycotoxins in food, helps delay chronic diseases and aging in animals and possibly in human beings.

Glycotoxins in the diet represent pathogenic compounds that have been linked to the induction and progression of many chronic diseases. High temperature and low moisture consistently and strongly drive their formation in foods. Comparatively brief heating time, low temperatures, high moisture, and/or pre-exposure to an acidified environment are effective strategies to limit new formation in food.

A significantly reduced intake of dAGEs can be achieved by reducing intake of solid fats, fatty meats, full-fat dairy products, and highly processed foods, and by increasing the consumption of legumes, vegetables, fruits, and whole grains. 

Low-AGE–generating cooking methods are 

  • poaching,
  • steaming,
  • stewing, 
  • boiling.

For example, the high AGE content of broiled chicken (5,828 kU/100 g) can be significantly reduced to 1,124 kU/100 g when the same piece of meat is either boiled or stewed. 

Future studies should continue to investigate the health effects of AGEs and refine recommendations for safe dietary intakes. However, current data support the need for a paradigm shift that acknowledges that how we prepare and process food may be equally important as nutrient composition.

Pythagoras

As long as Man continues to be the ruthless destroyer of lower living beings, he will never know health or peace.

Vitamin B12 Cobalamin

Vitamin B12, also called cobalamin, is a water-soluble vitamin that has a key role in the normal functioning of the brain and nervous system, and the formation of red blood cells. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism.

No fungi, plants, nor animals (including humans) are capable of producing vitamin B12. Only bacteria and archaea have the enzymes needed for its synthesis. Proved food sources of B12 are animal products (meat, fish, dairy products). Some research states that certain non-animal products possibly can be a natural source of B12 because of bacterial symbiosis.

B12 is the largest and most structurally complicated vitamin and can be produced industrially only through a bacterial fermentation-synthesis. This synthetic B12 is used to fortify foods and sold as a dietary supplement.

Vitamin B12 consists of a class of chemically related compounds (vitamers), all of which show pharmacological activity. It contains the biochemically rare element cobalt (chemical symbol Co). The vitamer is produced by bacteria as hydroxocobalamin, but conversion between different forms of the vitamin occurs in the body after consumption

B12 aids in lowering homocysteine levels and may lower the risk of heart disease. 

Recommended daily amount: 2.4 mcg

Example sources: fortified cereals, doenjang and chunggukjang (fermented soybeans), nori (seaweed). 

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