Vitamin B-12 status did not change significantly after treatment in the placebo group with daily supplementation with high doses of oral vitamin B-12 alone or in combination with folic acid.
Oral vitamin B-12 supplementation corrected mild vitamin B-12 deficiency.
Vitamin B-12 + folic acid supplementation increased red blood cell folate concentrations and decreased total homocysteine concentrations by 36%.
Improvement in memory function was greater in the placebo group than in the group who received vitamin B-12 alone. Neither supplementation with vitamin B-12 alone nor that in combination with folic acid was accompanied by any improvement in other cognitive domains.
A sharp distinction between humans and “animals” is essential if we are to bend them to our will, make them work for us, wear them, eat them–without any disquieting tinges of guilt or regret. It is unseemly of us, who often behave so unfeeling toward other animals, to contend that only humans can suffer. The behavior of other animals renders such pretensions specious. They are just too much like us.
Estimated Average Requirement (EAR) is the average daily nutrient intake level that is estimated to meet the requirements of half - 50% - of the healthy individuals in a particular life stage and gender group.
Because the needs of the other half of the population will not be met by this amount, the EAR is increased by about 20% to arrive at the RDA.
Before setting the EAR, a specific criterion of adequacy is selected, based on a careful review of the literature. When selecting the criterion, reduction of disease risk is considered along with many other health parameters.