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Supplementation of vitamin D is effective in preventing overall mortality in a long-term. It is not significantly effective in a treatment duration shorter than 3 years. 

Vitamin D therapy significantly decreased all-cause mortality with a duration of follow-up longer than 3 years. No benefit was seen in a shorter follow-up periods. 

The following subgroups of long-term follow-up had significantly fewer deaths:

  • female only,
  • participants with a mean age younger than 80,
  • daily dose of 800 IU or less,
  • participants with vitamin D insufficiency and cholecalciferol therapy.

The combination of vitamin D and calcium significantly reduced mortality and vitamin D alone also had a trend to decrease mortality in a longer time follow up.

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Linus Pauling

I have something that I call my Golden Rule. It goes something like this: 'Do unto others twenty-five percent better than you expect them to do unto you.' … The twenty-five percent is for error.

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