All about fruitarianism with a long-term fruitarian, Lena

Intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and cardiovascular disease risk. 

The study tested the carnitine and trimethylamine-N-oxide (TMAO) levels - a metabolite the researchers previously linked in a 2011 study to the promotion of atherosclerosis in humans - of omnivores, vegans and vegetarians, and examined the clinical data of 2,595 patients undergoing elective cardiac evaluations. The research finds that a diet high in carnitine promotes the growth of the bacteria that metabolize carnitine, compounding the problem by producing even more of the artery-clogging TMAO. 

Stanley Hazen, M.D., Ph.D.:

Carnitine metabolism suggests a new way to help explain why a diet rich in red meat promotes atherosclerosis.

The bacteria living in our digestive tracts are dictated by our long-term dietary patterns. A diet high in carnitine actually shifts our gut microbe composition to those that like carnitine, making meat eaters even more susceptible to forming TMAO and its artery-clogging effects. Meanwhile, vegans and vegetarians have a significantly reduced capacity to synthesize TMAO from carnitine, which may explain the cardiovascular health benefits of these diets.

Carnitine is naturally occurring in red meats, including beef, venison, lamb, mutton, duck, and pork. It is also a dietary supplement available in pill form and a common ingredient in energy drinks

Pythagoras

As long as Man continues to be the ruthless destroyer of lower living beings, he will never know health or peace.

Enterotypes and Microflora

An enterotype is a classification of living organisms based on its bacteriological ecosystem in the gut microbiome. Humans can be roughly divided into three enterotypes depending on which genus of bacteria dominates their gut: Bacteroides, Ruminococcus, or Prevotella. 

  • People who eat a lot of meat and saturated fat tended to have more Bacteroides in their flora
  • Ruminococcus prevailed in people who consumed lots of alcohol and polyunsaturated fats. 
  • Prevotella favored a diet rich in carbohydrates.

Long-term diet is strongly associated with the gut microbiome composition. If switching gut enterotype is possible, it may take a long-term dietary intervention. 

Chimpanzees have enterotypes that are compositionally analogous to those found in humans. 

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